IgG4 related disease in pancreas, bile duct and liver
نویسنده
چکیده
IgG4-related disease is a unique systemic inflammatory condition characterized by pseudotumorous formation or swelling of affected organs and high-serum IgG4 concentrations. Further studies have demonstrated that IgG4-related disease can involve a variety of organs including the pancreas ( type 1 autoimmune pancreatitis) , bile duct ( IgG4-related sclerosing cholangitis), liver (IgG4-related hepatitis and inflammatory pseudotumor), gallbladder (IgG4-related cholecystitis), salivary gland (IgG4-related sialadenitis),retroperitoeneum (IgG4-related retroperitoneal fibrosis), kidney (IgG4-related tubulointerstitial nephritis), lung (IgG4-related interstitial pneumonia, inflammatory pseudotumor), prostate (IgG4-related prostatitis), lymph node (IgG4-related lymphadenopathy) et al. Presence of typical histopathological features, including the existence of numerous IgG4 positive plasma cells within affected tissue, is the gold standard for the diagnosis of IgG4-related disease. Responsiveness to glucocorticoid is particularly characteristic early in the disease course, before the onset of significant tissue fibrosis. Increasing prevalence of IgG4 disease is reported worldwide.
منابع مشابه
Diagnosis and Follow-up of IgG4-related Disease Involving the Bile Ducts and Pancreas by using Magnetic Resonance Imaging: A case report
Immunoglobulin G4 (IgG4)-related disease involving the pancreas and bile ducts is an increasingly recognized syndrome, and serum IgG4 has been proposed as a biomarker for monitoring the disease activity and therapeutic response in most cases. However, there are few reports on the utility of magnetic resonance cholangiopancreatography (MRCP) as a marker of IgG4-related diseases, including its us...
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